A catalogue of cellular protocols.

The full treatment menu.

Every protocol below is a starting point. The cell type, dose, and delivery route are decisions made after the specialist physician reviews your case. Many protocols use Muse™ cells , a stress enduring, pluripotent subpopulation of mesenchymal stem cells. Learn about Muse cells →  ·  See pricing & estimate your cost →

Joint Therapies

Knee · Hip · Shoulder · Ankle

Knee

We treat your right knee, left knee, or both.

Cells are injected directly into the knee to calm inflammation, support cartilage, and ease the everyday movements that hurt first: stairs, kneeling, getting in and out of a chair.

  • Single UC MSC 20–30M
  • Single UC MSC 40–60M
  • Single Muse Cell · IV Homing
  • Single Muse Cell · Direct Injection
  • Single PRP + UC MSC
  • Single UC MSC 40M
  • Single Exosome + UC MSC
  • Both Knees UC MSC 40M each

Hip

We treat your right hip, left hip, or both, including the joint itself and the bone within.

Used for hip osteoarthritis and avascular necrosis (AVN). The goal is to reduce stiffness, protect the joint surface, and delay or avoid replacement surgery.

  • Single UC MSC 20–30M / Mild OA
  • Single UC MSC 40–60M / Moderate
  • Single UC MSC 100M / AVN
  • Single Muse Cell · IV / AVN
  • Single Muse Cell · Direct
  • Single PRP + UC MSC
  • Both Hips

Shoulder

We treat the main shoulder joint, the AC joint at the top of the shoulder, and the SC joint near the collarbone, on either side.

Helpful for rotator cuff injury, early arthritis, and persistent shoulder pain that limits reach, sleep position, or overhead movement.

  • Single UC MSC 20–30M / Early OA
  • Single UC MSC 40M / Rotator Cuff
  • Single Muse Cell
  • Single PRP + UC MSC
  • Both Shoulders

Ankle

We treat your right ankle, left ankle, or both.

Used for ankle arthritis, old sprains that never fully healed, and cartilage damage (OCD lesions): to restore stability and reduce the daily pain that comes with every step.

  • Single UC MSC / Mild OA
  • Single UC MSC / Advanced OA
  • Single Muse Cell
  • Single PRP + UC MSC / OCD
  • Both Ankles

Spine, Sacroiliac & TMJ

Disc · Facet · SI · TMJ

Spine (Back)

We treat the neck (cervical), mid back (thoracic), and lower back (lumbar), including the small facet joints that run alongside the spine.

Cells are delivered into discs, facet joints, or the epidural space, depending on whether your pain comes from disc degeneration, joint inflammation, or pinched nerves (radiculopathy).

  • Intradiscal Single Level (UC MSC)
  • Intradiscal Multi Level 2–3 (UC MSC)
  • Intradiscal Muse Cell · NP Regen
  • Facet Joints Bilateral (UC MSC)
  • Epidural Radiculopathy (UC MSC)
  • Intradiscal Exosome

Sacroiliac (SI)

We treat the sacroiliac joints, where your lower spine meets the pelvis, one side or both.

Often the hidden cause of low back, hip, or buttock pain that travels down the leg. Direct injection calms inflammation and restores comfortable movement.

  • Unilateral UC MSC
  • Bilateral UC MSC
  • Single Muse Cell

Jaw (TMJ)

We treat the jaw joint on one side or both.

Helpful for clicking, locking, chronic jaw pain, and disc problems that make eating, speaking, or even smiling uncomfortable.

  • Unilateral UC MSC
  • Bilateral UC MSC
  • Disc Protocol Muse Cell

Hand, Foot & Small Joints

Wrist · Elbow · Foot

Wrist & Hand

We treat the wrist, the knuckle joints (MCP and PIP), and the thumb's base joint (CMC), on either hand.

For arthritis in the small joints, thumb pain that makes pinching and gripping difficult, and tendon irritation like De Quervain's. The goal is to keep your hands strong for the things you do every day.

  • Wrist · Single UC MSC
  • Hand / Finger Joint UC MSC per joint
  • Wrist / Hand Muse Cell
  • Thumb CMC / De Quervain PRP + UC MSC

Elbow

We treat one or both elbows.

Used for tennis elbow, golfer's elbow, and arthritis: to calm tendon inflammation and restore the pain free bend and grip you've been missing.

  • Single UC MSC / OA
  • Tennis Elbow UC MSC
  • Single Muse Cell
  • Epicondylitis PRP + UC MSC
  • Both Elbows

Foot

We treat the forefoot joints, the big toe joint, and the plantar fascia along the bottom of the foot.

Helpful for big toe arthritis (hallux rigidus), plantar fasciitis, and the chronic foot pain that quietly changes how you walk and stand.

  • 1st MTP / Hallux Rigidus UC MSC
  • Plantar Fasciitis UC MSC
  • Foot · Single Muse Cell
  • Plantar PRP + UC MSC
  • Both Feet

IV Systemic Infusion

UC MSC · Muse · Exosome

Whole Body Protocols

  • UC MSC 50M · Anti inflammatory
  • UC MSC 100M · High Dose
  • Muse Cell 1.5×10⁷ · Standard
  • Muse Cell 3.0×10⁷ · High Dose
  • Exosome Systemic

Multi Joint Packages

Combined region visits

Combined Protocols

  • Both Knees UC MSC 40M each
  • Both Knees Muse Cell each
  • Knee + Hip UC MSC
  • Knee + Hip Muse Cell IV
  • Full Lower Extremity UC MSC
  • Articular + Muse Cell IV

Aesthetic & Vitality

Face · Hair · Skin · Longevity

Facial Rejuvenation

We treat the full face, under eye area, neck, décolleté, and the backs of the hands.

A regenerative approach to texture, fine lines, and overall radiance: working with your skin's own repair signals for natural, gradual renewal.

  • Mesotherapy UC MSC
  • Microneedle Exosome
  • Injection PRP + UC MSC
  • Topical Exosome serum

Hair Restoration

We treat the crown, hairline, beard, and eyebrows.

Stimulates dormant follicles to support thicker growth and slow further loss. Best for early to moderate thinning, not a substitute for transplant once follicles are gone.

  • Scalp PRP + UC MSC
  • Scalp Exosome microneedle
  • Maintenance Exosome series

Skin & Scarring

We treat acne scarring, stretch marks, burn scars, and surgical scars.

Regenerative signals are delivered into the damaged skin layers to remodel scar tissue and soften the look of indents, marks, and uneven tone over a series of sessions.

  • Local UC MSC
  • Microneedle Exosome
  • Combined PRP + UC MSC

Longevity & Vitality

Whole body protocols supporting energy, sleep, sexual wellness, and graceful aging.

Delivered intravenously to address systemic inflammation and cellular aging, for people who already feel well, but want to feel sharper, recover faster, and age on their own terms.

  • IV UC MSC 50M
  • IV UC MSC 100M
  • IV Muse Cell · Standard
  • IV Exosome · Systemic

Autoimmune & Inflammatory

RA · MS · Lupus · IBD · Thyroid

Rheumatic

For rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Sjögren's.

MSCs help recalibrate an overactive immune system: easing joint pain, swelling, and morning stiffness, and often reducing reliance on long term immunosuppressants.

  • IV UC MSC 50M
  • IV UC MSC 100M · High dose
  • IV Muse Cell · Standard

Connective & Skin

For lupus (SLE), scleroderma, psoriasis, and severe eczema.

Targets the immune driven inflammation behind skin and connective tissue flares, often improving both how things look on the surface and what the labs show underneath.

  • IV UC MSC 50M
  • IV UC MSC 100M
  • IV Exosome · Systemic

Gastrointestinal

For Crohn's disease, ulcerative colitis, IBS D, and post celiac inflammation.

Helps restore the gut lining and quiet the immune response that drives chronic GI symptoms: bloating, urgency, pain, and the fatigue that comes with malabsorption.

  • IV UC MSC 50M
  • IV UC MSC 100M
  • IV Muse Cell

Endocrine & Metabolic

For Hashimoto's thyroiditis, Graves' disease, type 1 diabetes, and chronic fatigue.

Used to calm autoimmune attacks on endocrine glands and support metabolic recovery. Works best alongside your endocrinology care, complementing it.

  • IV UC MSC 50M
  • IV UC MSC 100M · High dose
  • IV Muse Cell
  • IV Exosome · Systemic

Neurological & Cognitive

Stroke · Parkinson’s · SCI · TBI · Neuropathy

Stroke & Vascular

For recovery from ischemic and hemorrhagic stroke, and for vascular dementia.

Best started within the first months after the event. Cells support neuroplasticity and circulation in the brain tissue around the injury, working hand in hand with your physical and speech rehab.

  • IV UC MSC 100M
  • IV Muse Cell · High dose
  • Intrathecal UC MSC

Neurodegenerative

For Parkinson's, ALS, multiple sclerosis, and early Alzheimer's or mild cognitive impairment (MCI).

The aim is to slow progression and reduce neuroinflammation. A realistic goal is preservation of function, not reversal, and earlier intervention tends to help most.

  • IV UC MSC 100M
  • IV Muse Cell · High dose
  • IV Exosome · Systemic
  • Intrathecal UC MSC

Injury & Trauma

For spinal cord injury, traumatic brain injury, concussion aftereffects, and post surgical recovery.

Combines IV and intrathecal (spinal fluid) delivery to support nerve repair and reduce the chronic inflammation that lingers long after the initial injury heals.

  • IV UC MSC 100M
  • IV + Intrathecal UC MSC + Muse Cell
  • IV Exosome

Peripheral & Pain

For diabetic and chemotherapy induced neuropathy, idiopathic neuropathy, and complex regional pain syndrome (CRPS).

Targets damaged peripheral nerves to restore sensation and calm the burning, tingling, or chronic pain at its source.

  • IV UC MSC 50M
  • IV UC MSC 100M · High dose
  • Local UC MSC + PRP
  • IV Exosome · Systemic

Autism Spectrum Disorder (ASD)

UC-MSC · Exosome · Pediatric & adult

Emerging clinical research suggests umbilical-cord MSCs may help modulate neuroinflammation, support immune balance, and improve behavioral outcomes in children and adults with ASD. Personalized protocols are delivered under direct medical supervision.

How stem cells may help in ASD

Autism Spectrum Disorder is increasingly understood as involving neuroinflammation, immune dysregulation, and oxidative stress, in addition to developmental and genetic factors. Umbilical cord-derived MSCs work through several mechanisms that may address these underlying factors:

Anti-inflammatory effect

MSCs release cytokines and growth factors that help reduce chronic neuroinflammation, a key feature identified in multiple ASD studies.

Immune modulation

UC-MSCs help rebalance the immune system, particularly T-cell regulation, which may be dysregulated in a significant subset of ASD patients.

Neuroprotection & support

Stem cells secrete neurotrophic factors (BDNF, NGF) that support existing neural pathways and may encourage healthier connectivity over time.

Oxidative stress reduction

MSC-derived exosomes carry antioxidant signals that may reduce oxidative burden in the brain, another factor commonly elevated in ASD.

Important note

Stem cell therapy for ASD is an emerging treatment. TrueCell does not claim to cure autism. All treatment decisions are made by a board-certified physician after a thorough individual evaluation, and results vary by patient.

Cell type

UC-MSCs + exosomes

Umbilical-cord mesenchymal stem cells with exosomes, chosen for their immunomodulatory profile and ability to act on the central nervous system.

Delivery

IV infusion & intrathecal

The primary route is intravenous; in select cases intrathecal (lumbar) delivery may be recommended to maximize CNS exposure, as decided by the physician.

Dose

Personalized by weight & age

Dosage is calculated from body weight, age, severity, and history. Pediatric protocols are carefully adjusted for safety and tolerability.

Duration

3 to 5 day stay

Arrival, evaluation, one or two procedure sessions, and recovery observation before departure, confirmed in your virtual pre-consultation.

Lab standard

ISO-certified GMP lab

Cells are processed in an ISO-certified laboratory; viability, sterility, and identity are tested and documented before every application.

Follow-up

Remote monitoring included

Post-procedure follow-up at 30, 60, and 90 days, with progress tracked through standardized assessments shared with families.

Patients who may be good candidates

  • Children ages 2 to 17 with an ASD diagnosis

    Pediatric patients across the spectrum, from Level 1 to Level 3, are evaluated individually for suitability.

  • Adults with ASD seeking functional improvement

    Adults looking to address focus, anxiety, sensory sensitivity, and social processing may also be evaluated.

  • Patients with documented neuroinflammatory markers

    Lab results showing elevated inflammatory markers (cytokines, CRP) or immune dysregulation may indicate stronger candidacy.

  • Families who have exhausted conventional options

    Families who have explored ABA, speech therapy, and medication management increasingly turn to regenerative approaches for a next step.

What families commonly report

Improved verbal communication: increased vocabulary, more spontaneous speech, better sentence structure.
Better eye contact & social awareness: more present in interactions, increased interest in peers.
Reduced hyperactivity & sensory sensitivity: calmer responses to stimuli, fewer meltdowns, improved sleep.
Better focus & cognitive engagement: improved attention span and participation in structured activities.

Reported outcomes vary by patient. These are observations shared by families and do not constitute medical guarantees. All results are individual.

Enjoy a complimentary video call with one of our physicians.

Dr. Raúl López Serna

Questions about treatments?

If your question isn't here, our concierge replies personally within one business day.

How do I book a consultation?

Submit the consultation form with your imaging and history. Our concierge confirms a time within one business day. The consult itself is complimentary and conducted by a board certified physician.

What conditions are best treated with stem cells?

Joint and orthopedic indications (knee, hip, shoulder, spine, small joints), autoimmune and metabolic conditions, neurological cases, and longevity protocols. A physician confirms candidacy after reviewing your imaging and labs. We turn down candidates where joint replacement or another option will serve them better.

What does treatment cost?

Single joint UC MSC protocols typically begin in the mid five figure range. High dose IV and multi joint packages are quoted on the consult call once your physician confirms the plan. We provide an itemized quote before anything is scheduled. Clear, upfront pricing.

How long does a treatment visit take?

Joint injections take 20 to 40 minutes under ultrasound guidance with local anesthetic. IV protocols are a 60 to 90 minute infusion in a private suite. You walk out the same day. Most patients fly home the day after treatment.

Is the procedure painful?

For most patients, far less than expected. Joint injections use local anesthetic and are described as comparable to a standard intra articular injection. Mild post procedure soreness for 48 to 72 hours is common and resolves on its own with acetaminophen.

How quickly will I feel results?

Most patients report initial changes within 4 to 6 weeks and meaningful improvement at 3 to 6 months. Outcomes vary by indication, severity, and protocol. Aftercare check ins at 2, 6, and 12 weeks track progress objectively.

How is the dose decided?

Priced by indication, severity, imaging, and patient size. UC MSC dosing typically ranges from 20 million cells (early OA) to 100 million or more (AVN, high dose systemic). Your physician documents the rationale on your protocol sheet.

Will I need follow up treatments?

Most patients see meaningful improvement from a single visit. Some indications, like chronic autoimmune or advanced OA, benefit from a booster at 9 to 12 months. Your physician shares the expected trajectory during your consultation, up front.

Can I combine protocols in one visit?

Yes. Multi joint and articular plus systemic combinations are common and often more efficient. See our multi joint packages for typical pairings. Custom combinations are quoted on consult.

Are results guaranteed?

No legitimate regenerative practice will guarantee outcomes. We share aggregate response rates honestly. We will tell you if your case is unlikely to respond before you book. Honest "no" answers are how the "yes" earns its weight.

What's included in the price?

Physician consultation, cell preparation, in clinic procedure, recovery suite, and structured follow up at 2, 6, and 12 weeks. Travel and lodging are arranged separately by our concierge at preferred rates.

What aftercare do you provide?

Structured check ins at 2, 6, and 12 weeks, then 6 and 12 months. Your case manager remains reachable around the clock for the full two year follow up window. Discharge summary and protocol record are sent home with you and coordinated with your local physician where ongoing care is needed.

References — peer reviewed literature 7 citations

Citations support the general scientific basis for the regenerative protocols discussed on this page. They do not constitute claims of guaranteed outcomes for any individual patient. Stem cell therapies are not FDA approved for most conditions; protocols at TrueCell are provided under Mexican regulatory authority (COFEPRIS).

  1. Vega A, Martín Ferrero MA, Del Canto F, et al. Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial. Transplantation. 2015;99(8):1681–1690. PubMed ↗
  2. Matas J, Orrego M, Amenabar D, et al. Umbilical Cord Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial. Stem Cells Translational Medicine. 2019;8(3):215–224. PubMed ↗
  3. Pas HIMFL, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. British Journal of Sports Medicine. 2017;51(15):1125–1133. PubMed ↗
  4. Lamo Espinosa JM, Mora G, Blanco JF, et al. Intra articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis. Journal of Translational Medicine. 2016;14(1):246. PubMed ↗
  5. Kuroda Y, Kitada M, Wakao S, et al. Unique multipotent cells in adult human mesenchymal cell populations. Proceedings of the National Academy of Sciences USA. 2010;107(19):8639–8643. PubMed ↗
  6. Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A. PRP Injections for the Treatment of Knee Osteoarthritis: A Meta Analysis of Randomized Controlled Trials. Cartilage. 2021;13(1_suppl):364S–375S. PubMed ↗
  7. Centeno CJ, Al Sayegh H, Bashir J, Goodyear S, Freeman MD. A multi center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. International Orthopaedics. 2016;40(8):1755–1765. PubMed ↗